A significant seizure of a controlled substance has occurred, with over 1,000 pounds confiscated. This seizure led to the arrest of three individuals. The substance seized is khat, a controlled substance.

U.S. Customs and Border Protection was involved in the seizure, which took place at an airport. Further details about the incident are available from the source.

The seizure and subsequent arrests were made at Chicago O'Hare Airport, according to the information provided.